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At the United States Army Aeromedical Research Laboratory in Fort Rucker, Alabama, six pilots were kept awake continuously for two forty-hour periods.
They were given Modafinil in one session and a Placebo in the other.
The pilots were then evaluated in helicopter simulator flights, resting electroencephalograms (EEGs), and mood questionnaires.
The drug lessened the effects of sleep deprivation in four of six flight maneuvers tested compared to the placebo.
It also reduced slow-wave EEG activity (when one begins to fall asleep, EEG begins to slow) and decreased self-reported problems with mood and alertness.